6- Mercaptopurine
6-mercaptopurine (6-MP) is thiol analogue of hypoxanthine. 6-MP and 6- thioguanine are first purine analogue to be used as antineoplastic agent. It is included in […]
Pharmacology
Lamotrigine
Lamotrigine is 2nd generation antiepileptic drug which belongs to phenyltriazine class. It is included in World Health Organization’s List of Essential Medicines. It was developed […]
Trimethaphan
Introduction of Trimethaphan Trimethaphan is ganglionic blocking agent. It is used as nicotinic antagonist in hypertension. It inhibits both sympathetic and parasympathetic autonomic activity. Trimethaphan […]
Cimetidine
Cimetidine is histamine H2 receptor antagonist. H2 receptor antagonist are first class of drug used for treating peptic ulcer, but their use nowadays is surpassed […]
Lomitapide
Lomitapide is lipid lowering agent which reduces blood level of ‘bad’ cholesterol. It is recently approved for treatment of homozygous familial hypercholesterolemia. Lomitapide is an […]
Carmustine
Carmustine is an alkylating agent used as anti-neoplastic drug. It belongs to class of nitrogen mustard. Carmustine is β-chloro-nitrosourea compound (BCNU). Uses of carmustine Used […]
Chlorambucil
Chlorambucil is an aromatic nitrogen mustard derivative. It is a bifunctional alkylating agent and is commonly used chemotherapeutic agent. It was first synthesized by Everett […]
Alkylating agents
Alkylating agents are among the oldest and useful anti-neoplastic drugs. They are cytotoxic drugs and hence, act directly on cells. Before introduction of alkylating agents […]